![]() ![]() These events triggered a protocol amendment. He also had short-lived iatrogenic coma because of hypoglycemia secondary to insulin administration. He developed factitious hyperglycemia, as measured with a point-of-care glucometer, that persisted for 6 days after discontinuation of the study drug, confirmed to be vitamin C after unblinding. ![]() The patient was enrolled in LOVIT (Lessening Organ Dysfunction with VITamin C identifier: NCT03680274), a randomized placebo-controlled trial of high-dose intravenous vitamin C. We report a 73-year-old non-diabetic white man with end-stage renal disease on peritoneal dialysis admitted to the intensive care unit with septic shock that was suspected to be due to peritonitis. Yet, adverse events might be underreported and underappreciated. Proponents argue that the low cost and near perfect safety profile of vitamin C support its early adoption. High-dose vitamin C is increasingly used for sepsis and more recently for coronavirus disease 2019 (COVID-19) infections. ![]()
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